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What is Colchicine?

Colchicine also known as Colcrys is a gout treatment medication that is prescribed for the treatment of gout flares and Familial Mediterranean Fever. This anti-inflammatory drug cannot be used to treat pain that occurs due to other condition. Colcrys is recommended only for treating pain and inflammation that is caused due to gout or gout arthritis. Gout is caused due to the presence of excess amount of uric acid in the blood that may form hard crystals in the joints. It has been approved by most drug regulatory authorities globally for controlling pain and swelling caused due to gout. Colcrys is also used to prevent pain in the abdomen, chest or joints caused due to Familial Mediterranean Fever.

It is important for the patients to take the drug exactly as prescribed by their doctor. This will ensure optimum result from the treatment and reduce the risk of adverse effects.

• This medication can be taken by mouth with or without food
• One should stick to the doctor’s prescribed dosage and should never change the dose without prior consulting with the doctor.
• The drug should be taken immediately after the first sign of attack for the best result.
• Patients taking Colchicine for a longer duration need to get their blood tested on regular basis.
• Patients should never suddenly stop taking the medication even if they feel better.
• The tablet should not be broken or split.

Colcrys Prescribed Dosage

The correct dose of Colcrys is determined by doctors using several factors such as the patient’s age, medical condition for which they are being treated, their kidney and liver functions and other medications they might be taking. Thus, it is essential that patients stick to the dose prescribed by their doctor to achieve best result from the drug.

Colcrys Dosage for the treatment of Familial Mediterranean Fever

The recommended Colcrys dosages for adults and children for the treatment of FMF are:

• For children of age 4 to 6 years the recommended dose varies from 0.3 to 1.8 mg in a day.
• For children of age 6 to 12 years the recommended dose varies from 0.9 to 1.8 mg in a day.
• For patients above the age of 12 years the recommended dose of the drug varies from 1.2 to 2.4 mg in a day.

Colcrys Dose for the treatment of Gout:

Colcrys dosage for preventing gout attacks is one tablet once or twice in a day. The first tablet of 1.2 mg must be taken immediately after the first sign of a flare and the second tablet of 0.6 mg must be taken after one hour of the first dose.

Colchicine Missed and Overdose:

Missing a dose of Colcrys may not be harmful to a patient since it can be taken on a “as-needed basis” if instructed by the patient’s doctor. They can take the missed dose as soon as they remember and if it is the time for the next scheduled dose, patients should skip the missed dose and continue with their regular dosing schedule. Doubling the dose of the drug can cause adverse health effects. Overdose of Colcrys can prove fatal and dangerous for the patients and therefore they must cautiously use this drug. In case of overdose, the victim should receive immediate medical attention. They can also contact their local poison center for further directions. Some of the overdose symptoms include diarrhea, vomiting, nausea, heartburn, stomach pain, muscle weakness and numbness.

Colcrys Storage Instructions

Colcrys must be ideally stored at a temperature between 20-25 degrees C to maintain its efficacy and quality till the very end. The drug should be kept out of the reach of children and pets. It should be protected from direct sunlight and excessive moisture. Unused and expired drugs should be safely disposed of.

Patients taking Colchicine should be mindful of the following warnings. This will help them maximize the therapeutic outcome without causing any adverse effect on their health.

• Colcrys can cause serious muscle problems and blood disorders, especially in elderly patients.
• Before using the drug patients must inform doctor if they are allergic to this drug or if they are allergic to any other substances.
• Alcohol can decrease the efficiency of Colcrys so patients must limit or avoid drinking alcohol.
• Before undergoing any surgery patients must inform about their use of Colcrys.
• This drug should be avoided by the pregnant women and lactating mothers.
• Patients should avoid grapefruit or grapefruit juice while being treated with this medication.

Patients suffering from the following disease should discuss with their doctor prior to taking Colcrys to avoid further health complications:

• Liver disease
• Kidney disease
• Allergies to food, dyes or preservatives

Colcrys is prescribed to the patients only after determining if its benefit outweighs the risk. Most patients using this drug do not experience any side effect. In very rare cases it is observed that patients experience some side effects. The more common side effects of the drug usually exist during the initial phase of the treatment. Some of the Colcrys common side effects include:

• Diarrhea
• Nausea
• Muscle cramping
• Abdominal pain
• Vomiting
• Constipation
• Dizziness
• Difficulty in Swallowing

Serious Side Effects of Colchicine :

On occasion, a patient may experience the less common but more severe side effects of the medication. In such cases, patients must immediately stop using Colchicine and report it to the doctor. Serious side effects that can be experienced include:

• Unusual bleeding or bruising
• Severe diarrhea
• Muscle weakness or pain
• Vomiting
• Numbness or tingling in fingers or toes
• Pale color of the lips or tongue
• Signs of infection like fever and persistent sore throat
• Unusual weakness or tiredness

Colcrys Drug Interactions

Colcrys’ pharmacological effects can change or alter if this drug is taken along with certain medications. Therefore patients prescribed with this drug must inform their doctor about all prescription, non-prescription, herbal or dietary supplement taken by them. It is essential for the patients to be aware of medications that may interact with this drug. They should consult with their pharmacist or doctor while taking Colcrys and any other medications. Following drugs are not recommended along with Colchicine:

• Azole antifungals such as Itraconazole and ketoconazole
• Cyclosporine
• HIV medications such as ritonavir
• Antibiotics such as clarithromycin and erythromycin
• Telithromycin
• Verapamil
• Atorvastatin
• Digoxin
• Gemfibrozil
• Fenofibrate
• Pravastatin
• Simvastatin

Q: Why is Colcrys prescribed?

A: Colcrys is taken for the treatment of gout flares and Familial Mediterranean Fever. 

Q: How long until I see the effects of Colcrys?

A: If you are taking Colcrys 0.6mg to relieve gout attack symptoms, relief usually begins within 12 hours 

Q: What if I miss a dose of Colcrys?

A: Missing a dose of Colcrys may not be harmful to a patient since it can be taken on an “as-needed basis” if instructed by the patient’s doctor. They can take the missed dose as soon as they remember and if it is the time for the next scheduled dose, patients should skip the missed dose and continue with their regular dosing schedule. Doubling the dose of the drug can cause adverse health effects.

Q: How should I store this medication?

A: Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature (between 20-25 degrees C) and away from excess heat and moisture (not in the bathroom). This way Colcrys will maintain its efficacy and quality till the very end.

Q: How to treat gout?

A: Gout can be treated by using colchicine reguarly as prescribed by your doctor.